Exscientia Announces First-in-Human Study for Bristol Myers Squibb In-Licensed PKC Theta Inhibitor, EXS4318

Exscientia Announces First-in-Human Study for Bristol Myers Squibb In-Licensed PKC Theta Inhibitor, EXS4318

OXFORD, UK–(BUSINESS WIRE). The compound is in development for immunology and inflammatory (I&I) indications. Bristol Myers Squibb will oversee clinical and commercial development and Exscientia is eligible for milestone payments and, if approved, tiered royalties on net product sales.

“We are pleased that Bristol Myers Squibb is beginning clinical testing of ‘4318, the first Exscientia I&I candidate to enter the clinic. PKC-theta is an attractive immunomodulatory drug target; however, it has been a challenge for the field to develop a small molecule with the required potency and selectivity over other closely related kinases,” said David Hallett, Ph.D., Chief Scientific Officer at Exscientia. “Our expert-led AI design platform was able to deliver a balanced candidate that has demonstrated high targeted activity while maintaining high selectivity and a favorable therapeutic index in IND-enabling studies.This is a significant milestone for Exscientia, demonstrating the power and flexibility of our precision design platform in the efficient development of high-quality therapeutics.”

Experts searching for drugs using the company’s AI platform for generative design identified EXS4318 within 11 months of design initiation and was the 150thth novel compound synthesized in this program. The target product profile was particularly challenging due to the need for sustained, high target inhibition to enhance efficacy, as well as the requirement for a low daily dose in humans. PKC theta is structurally similar to several related kinases, making it difficult to achieve the high selectivity required to avoid off-target effects.

PKC theta, formerly known as Kinase X by Exscientia, was one of the first small molecule programs to form part of the original 2019 collaboration between Bristol Myers Squibb and Celgene. In May 2021, Bristol Myers Squibb and Exscientia expanded I&I and oncology collaboration, with increased economics for Exscientia. EXS4318 is the fourth drug candidate invented by Exscientia to enter the clinic.

About PKC theta

PKC theta plays a critical role in controlling T cell function and is a major driver of several common autoimmune diseases. PKC-theta inhibitors have potential in inflammatory and immunological diseases.

About Exscientia

Exscientia is an AI-driven pharmatech company dedicated to discovering, designing and developing the best possible medicines in the fastest and most effective way. Exscientia has developed the first-ever precision functional oncology platform to successfully guide treatment choice and improve patient outcomes in a prospective interventional clinical trial and bring AI-engineered small molecules to the clinical setting. Our internal pipeline is focused on leveraging our precision medicine platform in oncology, while our partnered pipeline is expanding our approach into other therapeutic areas. We believe that by pioneering a new approach to drug manufacturing, the best ideas in science can quickly become the best medicines for patients.

Visit us at https://www.exscientia.ai or follow us on Twitter @exscientiaAI.

Exscientia Forward-Looking Statements

This press release contains forward-looking statements, as that term is defined under the Private Securities Litigation Reform Act of 1995, including with respect to the progress of discovery and development of candidate molecules and the timing and progress of and data reported from clinical trials using the Exscientia product candidates. Any statement that describes Exscientia’s goals, plans, expectations, projections, intentions or beliefs is a forward-looking statement and should be considered a risky statement. Such statements are subject to a number of risks, uncertainties and assumptions, including those related to: the initiation, scope and progress of Exscientia’s and its partners’ planned and ongoing preclinical and clinical trials and their implications; clinical, scientific, regulatory and technical developments; the process of discovering, developing and commercializing product candidates that are safe and effective for use as human therapeutics; and seeking to build a business around such product candidates. Given these risks and uncertainties and other risks and uncertainties described in the “Risk Factors” section and other sections of Exscientia’s Annual Report on Form 20-F filed with the Securities and Exchange Commission (SEC) on March 23, 2022 ( File No. 001-40850) and other filings Exscientia makes with the SEC from time to time (which are available at https://www.sec.gov/) that the events and circumstances discussed in such forward-looking statements will not occur , and Exscientia’s actual results could differ materially and adversely from those anticipated or implied. Although Exscientia’s forward-looking statements reflect management’s good faith judgment, these statements are based only on facts and factors currently known to the company. Therefore, you are cautioned not to rely on these forward-looking statements.

Bristol Myers Squibb Cautionary Statement Regarding Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, relating to, among other things, research, development and commercialization of pharmaceutical products and collaborations. All statements other than statements of historical fact are, or may be deemed to be, forward-looking statements. Such forward-looking statements are based on current expectations and projections about our future financial results, goals, plans and objectives and involve inherent risks, assumptions and uncertainties, including internal or external factors that could delay, deviate or change them over the next several years, the are difficult to predict, are beyond our control and could cause our future financial results, goals, plans and objectives to differ materially from those expressed or implied by the statements. These risks, assumptions, uncertainties and other factors include, among others, that anticipated benefits and opportunities related to Bristol Myers Squibb’s collaboration may not be realized or that realization may take longer than anticipated, Bristol Myers Squibb could fail to be commercially successful discover and develop product candidates through the collaboration, and that the product candidate may not meet its primary study endpoints or receive regulatory approval for the indications described in this press release in the currently anticipated timeframe, or at all, and, if approved, whether such product candidate for the indications described in this press release will be commercially successful.

No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many risks and uncertainties affecting Bristol Myers Squibb’s business and market, particularly those discussed in the cautionary statements and discussion of risk factors in Bristol Myers Squibb’s Annual Report on Form 10- K are listed for the year ended December 31, 2021, updated by our subsequent quarterly reports on Form 10-Q, current reports on Form 8-K and other filings with the Securities and Exchange Commission. The forward-looking statements contained in this document speak only as of the date of this document and, except as otherwise required by applicable law, Bristol Myers Squibb undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, changes circumstances or otherwise.

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